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Literatuur
Vardenafil Drug Evaluation
Jay M Young
Expert Opinion investig. Drugs (2002) 11(10); 1487-1496

Vardenafil hydrochloride is a potent and highly selective inhibitor of phos-phodiesterase Type 5 that increases blood flow to the penis during sexual stimulation and helps restore the ability to achieve and sustain an erection in men with erectile dysfunction. Vardenafil was developed specifically to be an effective and safe oral medication for the treatment of erectile dysfunction, with potential advances over existing therapies. This review summarises key findings during the rapid and aggressive development of this compound, from in vitro assays to Phase III trials with both broad and special popula-tions. Emphasis is placed on the presentation of data that demonstrates the clinical effectiveness and safety of this agent which is anticipated to be avail-able in 2003.